Necessity of secretome data integration in the context of biological meaning
Cell secretomes comprise proteins that are secreted or shed from the cell surface, as well as intracellular proteins released into the supernatant due to vesiculation, cell lysis, apoptosis, and necrosis. ...Generating Gluten-Free and Hypoallergenic Wheat to Protect Patients with Wheat Allergy and Celiac Disease
To date no single test of antibody levels such as IgE, IgG, IgG4, IgA can confidently establish the diagnosis of food allergies...How two new ambient ionization methods have changed the way, with mass spectrometric analysis now being carried out, outside in the open.
Since 2004 a number of new ‘open air’ sources where introduced that have revolutionized the way that samples are introduced into an ion source for mass spectrometric analysis. This has resulted in the rapid analysis, with no special sample preparation or treatment for a wide variety of samples not suitable or difficult to analyze prior to their introduction...A Perspective On the New Paradigm of Diabetes Management Part 1
Most frequently when diabetes is suspected, it is the conventional wisdom to order a fasting glucose (no food or drink except water after midnight) or hemoglobin A1c (HbA1c). In all practicality, 2hPP glucose level or 2hPP glucose level or 2 hour oral glucose tolerance test is more affirmative than fasting glucose or HbA1c in defining diagnosis of diabetes....The Impact of Genomics in the Understanding of Signal Transduction Pathways
Evidence has highlighted that the alteration of one or more signal transduction pathways is involved in a growing number of human diseases, both degenerative and tumoral. In fact, the “social control” which cells undergo becomes evident when it fails. That is, every human disease might be seen as a “signalling disease”. ...