Exhausted cancer-killing cells help tumors by suppressing the immune system, study finds
Exhausted T cells switch from attacking to helping cancers in low-oxygen environments, pointing to a new way to improve the efficacy of immuno-oncology drugs, according to a study published on Wednesday in Nature Immunology. Read More
New hope for glioblastoma patients
Researchers at Cold Spring Harbor Laboratory have discovered a vulnerability within the brain cancer glioblastoma, in the form of a protein called BRD8. Their research, published on Wednesday in Nature, may finally lead to new treatment options and better patient outcomes for this often-fatal disease. Read More
Computer-generated marker of coronary artery disease may enable more targeted diagnosis
Researchers at the Icahn School of Medicine at Mount Sinai in New York have developed an in silico, or computer-derived, marker for coronary artery disease (CAD) that they believe could lead to better measurements of clinically important characterizations of the disease. Read More
Ebola vaccine protocols found safe for all ages
Two randomized, placebo-controlled trials evaluating three Ebola vaccine administration strategies in adults and children found that all regimens were safe in both age groups. The research, published last week in the New England Journal of Medicine, was conducted under the international consortium Partnership for Research on Ebola Vaccination (PREVAC). Read More
AMP assesses clinical implementation of past standards, guidelines for sequence variants in cancer
The Association for Molecular Pathology (AMP) on Tuesday announced that it has published a report to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” Read More
Preclinical KRAS inhibitor triggers complete responses in pancreatic tumors
A small molecule KRASG12D inhibitor has triggered complete responses in preclinical pancreatic cancer models, raising hopes that the approach can improve outcomes in the hard-to-treat tumor type. Read More
Overexpression of estrogen receptor gene linked to breast cancer risk in older women
A first-of-its-kind mouse model of aging finds overexpression of the estrogen receptor 1 gene could increase the risk of estrogen receptor-positive breast cancer in postmenopausal women, according to research published December 1 in the American Journal of Pathology. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
Blocking cell plasticity is essential to tackling glioblastomas: review
Therapeutics that restrain the plasticity of glioblastoma are essential to improving outcomes in patients with the lethal, hard-to-treat brain cancer, according to researchers at Australia's Flinders University. Read More
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