Currently, Flame is developing mAbs that bind and neutralize interleukin-1β (IL-1β) with the intention of treating multiple diseases, specifically cancer. Clinical research shows that IL-1β is a key mediator of the chronic inflammation that causes tumor growth, and Flame's IL-1β neutralizing antibody FL-10 has the potential to treat cancer effectively, according to the company.

FL-101 will enter the clinic for proof-of-concept testing in patients with non-small cell lung cancer in the first half of 2021.

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