Stem cell-loaded plug improves outcomes in hard-to-treat Crohn’s disease patients
March 3, 2023 -- Most Crohn’s disease patients experienced complete clinical healing of perianal fistulas after treatment with a stem cell-loaded plug, according to data published in the journal Diseases of the Colon & Rectum. Read More
At SLAS 2023, companies showcase, launch advanced automation and screening technologies
February 28, 2023 -- At the Society for Laboratory Automation and Screening (SLAS) 2023 International Conference and Exhibition, being held in San Diego from February 25 to March 1, numerous firms have announced that they are showcasing emerging technologies for advanced life science applications. Read More
Beckman Coulter, Sciex collaborate on high-throughput screening workflows
February 27, 2023 -- Life science analytical technologies company Sciex on Monday announced a collaboration with Beckman Coulter Life Sciences to provide comprehensive workflows for high-throughput screening; high-throughput absorption, distribution, metabolism, and excretion (HT-ADME); and synthetic biology studies. Read More
Algorithm predicts success of next-generation CRISPR edits, advancing push to treat genetic diseases
February 16, 2023 -- A machine learning algorithm has predicted the chances of successfully inserting a gene-edited sequence of DNA into a cell using a next-generation CRISPR-Cas9 approach. Read More
Adaptive Biotechnologies Q4 revenues rise 46% on NGS test volumes
February 15, 2023 -- Adaptive Biotechnologies on Tuesday reported fourth-quarter revenue of $55.2 million, up 46% compared with $37.9 million in Q4 2021. Read More
Challenges and remedies for manufacturing cell therapies at scale
February 3, 2023 -- Cell therapies have the potential to cure human diseases rather than just treat the symptoms, and they are potentially life-changing if they can be administered early in a patient’s lifetime. Read More
Aston University partners with longevity biotech to advance lung disease treatment
January 25, 2023 -- Aston University's work on small molecule inhibitors of transglutaminase 2 has spawned a biotech firm focused on treating the chronic lung disease idiopathic pulmonary fibrosis. Read More
Newborn screening for neuromuscular disorder leads to improved outcomes in Australian study
January 18, 2023 -- Newborn screening for spinal muscular atrophy (SMA) improves outcomes by enabling timely access to disease-modifying therapy, a prospective study published in the Lancet Child & Adolescent Health found. Read More
T-cell therapy fights viral infections following stem cell transplants
January 13, 2023 -- Baylor College of Medicine and Washington University School of Medicine researchers studied posoleucel, an investigational off-the-shelf T-cell therapy that simultaneously targets six different viruses. The results, published January 11 in the journal Clinical Cancer Research, showed promising antiviral efficacy and safety in a phase II clinical trial of patients who had undergone stem cell transplantation to treat blood diseases including cancer. Read More
Optimizing AAV vectors for gene therapy delivery
January 10, 2023 -- Adeno-associated viruses (AAV) can be engineered to deliver DNA to target cells. It is used extensively for the development of viral vector-based gene therapies in the pipeline. However, researchers encounter challenges with producing sufficient quantities of AAVs for gene therapy products, and they struggle to get delivery vehicles and their genetic payloads into the brain across the blood-brain barrier. Read More
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