NIH initiative to test new cancer drug combinations
The National Institutes of Health’s (NIH’s) National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of new cancer drug combinations, guided by tumor biology. The initiative, called Combination Therapy Platform Trial with Molecular Analysis for Therapy Choice (ComboMATCH), aims to identify promising treatments that can then advance to larger, more definitive clinical trials. Read More
Long COVID symptoms reported by 17% of unvaccinated people
Swiss researchers have found that about 17% of unvaccinated people report experiencing COVID-19-related health problems up to two years after SARS-CoV-2 infection. Read More
Deep sequencing captures genetic variants for vascular anomalies
Children’s Hospital of Philadelphia (CHOP) researchers found that deep sequencing of the genome in the tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies revealed genetic variants previously not captured by conventional genetic sequencing methods. The research, published Thursday in the journal Nature Medicine, led to improvements in over 60% of the patients placed on targeted therapies related to these newly found genetic variants. Read More
Cryo-electron microscopy sheds light on key step in replication of SARS-CoV-2
Researchers have used cryo-electron microscopy (cryo-EM) to visualize a critical step in the replication of SARS-CoV-2, generating insights that could inform the development of COVID-19 drugs. Read More
Nanozyme approach targets fungal infection
A nanozyme-based robotics approach could allow doctors to target and kill fungal pathogens at the sites of infection, according to a group at the University of Pennsylvania. Read More
Stem cell therapy targets brain metastatic melanomas
Twin stem cells acting in unison may activate the immune system to suppress metastatic melanoma tumor growth in the brain, according to Department of Defense-funded research, published Wednesday in Science Translational Medicine. The procedure prolonged survival in preclinical trials on mice, indicating that locally delivered immunotherapies may be beneficial in brain metastases treatment. Read More
COVID-19’s ‘long tail’ analyzed at European rheumatology congress
Researchers have found that people with inflammatory rheumatic diseases show no increased susceptibility to long COVID. This and other studies are being presented at the European Alliance of Associations for Rheumatology (EULAR) 2023 Congress in Milan from May 31 to June 3. Read More
Nucleai, Adlai Nortye collaborate on biomarkers for clinical trials
Artificial intelligence firm Nucleai and biopharmaceutical firm Adlai Nortye on Wednesday announced a strategic partnership aimed at identifying, validating, and testing novel H&E-based biomarkers in Adlai Nortye’s phases II and III clinical trials. Read More
Bacteria vary between early- vs. late-onset colorectal cancer tumors: Study
Researchers at Georgetown University’s Lombardi Comprehensive Cancer Center studied the microbiomes of people with colorectal cancer and found that the makeup of bacteria, fungi, and viruses in their tumors varied significantly depending on whether they had early-onset (age 45 or younger) or late-onset (age 65 or older) disease. Read More
Single-cell RNA sequencing data reveals T cells linked to cancer immunotherapy resistance
Single-cell RNA sequencing data has revealed an immune signature associated with non-responses to checkpoint inhibitors that may be a driver of resistance to immunotherapy. Read More
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